Dr. Ehsan Amin

Education & Degrees

Professional experience

Publications

2025

• Fehrentz, T., Amin, E., Görldt, N., Strasdeit, T., Moussavi-Torshizi, S.E., Leippe, P., Trauner, D., Meyer, C., Frey, N., & Sasse, P., et al. (2025). Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2. British Journal of Pharmacology.
• Fehrentz, T., Amin, E., Görldt, N., Strasdeit, T., Moussavi-Torshizi, S.E., Leippe, P., Trauner, D., Meyer, C., Frey, N., & Sasse, P., et al. (2025). Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2. British Journal of Pharmacology.

2023

• Wagner, J.U.G., Tombor, L.S., Malacarne, P.F., Kettenhausen, L.M., Panthel, J., Kujundzic, H., Manickam, N., Schmitz, K., Cipca, M., Stilz, K.A., et al. (2023). Aging impairs the neurovascular interface in the heart. Science, 381(6660), 897–906.
• Bazgir, F., Nau, J., Nakhaei-Rad, S., Amin, E., Wolf, M.J., Saucerman, J.J., Lorenz, K., & Ahmadian, M.R. (2023). The microenvironment in the pathogenesis of cardiac hypertrophy. Cells, 12(13), 1780.
• Moussavi-Torshizi, S.E., Amin, E., & Klöcker, N. (2023). Sex-specific repolarization heterogeneity in the mouse left ventricle: Optical mapping combined with mathematical modeling predicts the contribution of specific ionic currents. Physiological Reports, 11(11), e15670.
• Bottermann, K., Spychala, A., Eliacik, A., Amin, E., Moussavi-Torshizi, S.E., Klöcker, N., Gödecke, A., & Heinen, A. (2023). Extracellular flux analysis in intact cardiac tissue slices—A novel tool to investigate cardiac substrate metabolism in mouse myocardium. Acta Physiologica, 239(2), e14004.
• Angendohr, D.S., Dannenberg, D.L., Amin, D.E., Scherschel, D.K., Benkhoff, M., Baensch, L., Weber, J., Gerdes, N., Polzin, D.A., Rana, D.O., et al. (2023). Sustained high-fat diet increases ventricular susceptibility to arrhythmias and impairs myocardial calcium cycling. Europace, 25(Suppl 1), euad122-585.

2022

• Heinen, A., Bottermann, K., Spychala, A., Eliacik, A., Amin, E., Moussavi-Torshizi, S.E., Klöcker, N., & Gödecke, A. (2022). A New Method to Analyze Myocardial Substrate Metabolism and Mitochondrial Function in Intact Cardiac Tissue Slices. The FASEB Journal, 36.

2021

• Mosaddeghzadeh, N., Nouri, K., Krumbach, O.H.F., Amin, E., Dvorsky, R., & Ahmadian, M.R. (2021). Determinants of selectivity in RHO GTPase binding to IQGAPs. International Journal of Molecular Sciences, 22(22), 12596.
• Scherschel, K., Bräuninger, H., Mölders, A., Erlenhardt, N., Amin, E., Jungen, C., Pape, U., Lindner, D., Chetkovich, D.M., Klöcker, N., et al. (2021). Characterization of the HCN interaction partner TRIP8b/PEX5R in the intracardiac nervous system of TRIP8b-deficient and wild-type mice. International Journal of Molecular Sciences, 22(9), 4772.
• Adariani, S.R., Jasemi, N.S.K., Bazgir, F., Wittich, C., Amin, E., Seidel, C.A.M., Dvorsky, R., & Ahmadian, M.R. (2021). A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners. Journal of Biological Chemistry, 296.

2019

• Amin, E., Saboury, A.A., Mansouri-Torshizi, H., & Zolghadri, S. (2019). Inhibition Properties and Thermodynamic Changes of the Binding of p-Perazine-bis and p-Peridine Dithiocarbamate Sodium Salts to Mushroom Tyrosinase. Iranian Journal of Chemistry and Chemical Engineering, 38(3), 127–136.
• Martinelli, S., Krumbach, O., Pantaleoni, F., Coppola, S., Amin, E., Pannone, L., Nouri, K., Farina, L., Dvorsky, R., Lepri, F., et al. (2019). Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes. In European Journal of Human Genetics, 27, 833–833.

2018

• Martinelli, S., Krumbach, O.H.F., Pantaleoni, F., Coppola, S., Amin, E., Pannone, L., Nouri, K., Farina, L., Dvorsky, R., Lepri, F., et al. (2018). Functional dysregulation of CDC42 causes diverse developmental phenotypes. The American Journal of Human Genetics, 102(2), 309–320.
• Amin, E., & Ahmadian, M.R. (2018). Regulators of Rho signaling. In Rho GTPases: Molecular Biology in Health and Disease (pp. 33–51).

2016

• Amin, E., Jaiswal, M., Derewenda, U., Reis, K., Nouri, K., Koessmeier, K.T., Aspenström, P., Somlyo, A.V., Dvorsky, R., & Ahmadian, M.R. (2016). Deciphering the molecular and functional basis of RHOGAP family proteins: a systematic approach toward selective inactivation of RHO family proteins. Journal of Biological Chemistry, 291(39), 20353–20371.
• Becker, M.S., Müller, P.M., Bajorat, J., Schroeder, A., Giaisi, M., Amin, E., Ahmadian, M.R., Rocks, O., Köhler, R., Krammer, P.H., et al. (2016). The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration. Oncotarget, 7(32), 51908.
• Nouri, K., Fansa, E.K., Amin, E., Dvorsky, R., Gremer, L., Willbold, D., Schmitt, L., Timson, D.J., & Ahmadian, M.R. (2016). IQGAP1 interaction with RHO family proteins revisited: kinetic and equilibrium evidence for multiple distinct binding sites. Journal of Biological Chemistry, 291(51), 26364–26376.
• Nakhaeizadeh, H., Amin, E., Nakhaei-Rad, S., Dvorsky, R., & Ahmadian, M.R. (2016). The RAS-effector interface: Isoform-specific differences in the effector binding regions. PLoS ONE, 11(12), e0167145.

2015

• Dütting, S., Heidenreich, J., Cherpokova, D., Amin, E., Zhang, S.-C., Ahmadian, M.R., Brakebusch, C., & Nieswandt, B. (2015). Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets. Journal of Thrombosis and Haemostasis, 13(5), 827–838.
• Nouri, K., Moll, J.M., Milroy, L.-G., Hain, A., Dvorsky, R., Amin, E., Lenders, M., Nagel-Steger, L., Howe, S., Smits, S.H.J., et al. (2015). Biophysical characterization of nucleophosmin interactions with HIV Rev and HSV US11. PloS ONE, 10(12), e0143634.
• Nakhaeizadeh, H., Nakhaei-Rad, S., Amin, E., Kordes, C., Häussinger, D., & Ahmadian, M.R. (2015). The impact of the interaction between embryonic stem cell-expressed Ras and Arginase-1 in hepatic stellate cells. Zeitschrift für Gastroenterologie, 53(12), A3_30.

2014

• Jaiswal, M., Dvorsky, R., Amin, E., Risse, S.L., Fansa, E.K., Zhang, S.-C., Taha, M.S., Gauhar, A.R., Nakhaei-Rad, S., Kordes, C., et al. (2014). Functional cross-talk between Ras and Rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of the deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger. Journal of Biological Chemistry, 289(10), 6839–6849.
• Zhang, S.-C., Nouri, K., Amin, E., Taha, M.S., Nakhaeizadeh, H., Nakhaei-Rad, S., Dvorsky, R., & Ahmadian, M.R. (2014). Classical Rho Proteins: Biochemistry of Molecular Switch Function and Regulation. In Ras Superfamily Small G Proteins (pp. 327–340). Springer Vienna.
• Jaiswal, M., Dvorsky, R., Amin, E., Risse, S.L., Fansa, E.K., Zhang, S.C., & Taha, M.S. (2014). Functional crosstalk between Ras and Rho pathways: p120RasGAP competitively inhibits the RhoGAP activity of Deleted in Liver Cancer (DLC) tumor suppressors by masking its catalytic arginine finger. In vitro Liposome Reconstitution of Intracellular Small GTPase Signal Transduction, 34.

2013

• Amin, E., Dubey, B.N., Zhang, S.-C., Gremer, L., Dvorsky, R., Moll, J.M., Taha, M.S., Nagel-Steger, L., Piekorz, R.P., Somlyo, A.V., et al. (2013). Rho-kinase: regulation, (dys)function, and inhibition. Biological Chemistry, 394(11), 1399–1410.

2010

• Amin, E., Saboury, A.A., Mansuri-Torshizi, H., & Moosavi-Movahedi, A.A. (2010). Potent inhibitory effects of benzyl and p-xylidine-bis dithiocarbamate sodium salts on the activity of mushroom tyrosinase. Journal of Enzyme Inhibition and Medicinal Chemistry, 25(2), 272–281.
• Amin, E., Saboury, A.A., Mansouri-Torshizi, H., Zolghadri, S., & Bordbar, A.K. (2010). Evaluation of p-phenylene-bis and phenyl dithiocarbamate sodium salts as inhibitors of mushroom tyrosinase. Acta Biochimica Polonica, 57(3), 277–283.
• Zolghadri, S., Saboury, A.A., Amin, E., & Moosavi-Movahedi, A.A. (2010). A spectroscopic study on the interaction between ferric oxide nanoparticles and human hemoglobin. Journal of the Iranian Chemical Society, 7, S145–S153.